NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/ng.2007.38; PubMed=18037886 [NCBI, ExPASy, EBI, Israel, Japan]
Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.;
"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors.";
Nat. Genet. 39:1469-1476(2007).

Comments

FUNCTION: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity).
CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate + NADP⁺ = L-glutamyl 5-phosphate + NADPH.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the gamma-glutamyl phosphate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AM260525; CAK00658.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

A9IMB2.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350;	Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00412; -; 1.
PBIL [Tree]

InterPro

IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11063:SF1; GSA_DH; 1.

PIRSF000151; GPR; 1.

TIGR00407; proA; 1.

PS01223; PROA; 1.

Genome annotation databases

GenomeReviews

AM260525_GR; BT0174.

CMR

A9IMB2; BT0174.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 409`	`409`		`Gamma-glutamyl phosphate reductase.`	`PRO_0000340872`

Sequence information

Length: 409 AA [This is the length of the unprocessed precursor]

Molecular weight: 44016 Da [This is the MW of the unprocessed precursor]

CRC64: 799420BB60213866 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGQKARSAAA ALAVASSEQK NNALEMIALS LEAHSDEILR ANCLDLEKAT QNNLKAAMVD 

        70         80         90        100        110        120 
RLKLDELRLA AMIDSVRQVA RLSDPVGQIM SAWTRPNGLH ISRVRTPLGV IGIIYESRPN 

       130        140        150        160        170        180 
VTIDASSLCL KAGNAVILRG GSDSFHSSYA LHCALVQGLE HSGLPKSAIQ MVGTTDRAAV 

       190        200        210        220        230        240 
GEILKGLDGA IDVIVPRGGK SLVARVQSDA RVPVFAHLEG LCHIYIDKSA DLDMARNIVL 

       250        260        270        280        290        300 
NAKLRRTGIC GAVETVLIDN EALKKFLPVL TALQEKGCEI RATEDIAFLV PDVKLASEED 

       310        320        330        340        350        360 
WSHEYLDAIL SVKTVEGVEG AISHIKRYSS GHTESIIAED MEVVKKFFNH LDSAILLHNA 

       370        380        390        400 
STQFADGGEF GFGMEIGIAT GKMHARGPIG VEQLTSFQYH IKGNGQVRA

A9IMB2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools