[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Crossbred X Angus; TISSUE=Liver; NIH - Mammalian Gene Collection (MGC) project; Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate (Probable).
CATALYTIC ACTIVITY: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2 .
SIMILARITY: Belongs to the proline oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC149682; AAI49683.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001098437.1; -.

UniGene

Bt.5124

3D structure databases

ModBase

A6QQ74.

Ontologies

GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002872; Proline_DHase.
IPR015659; Proline_oxidase.
Graphical view of domain structure.

PANTHER

PTHR13914; Proline_oxidase; 1.

Pfam

PF01619; Pro_dh; 1.
Pfam graphical view of domain structure.

Genome annotation databases

Ensembl

ENSBTAG00000031772; Bos taurus. [Contig view]

GeneID

508542; -.

KEGG

bta:508542; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Flavoprotein; Oxidoreductase; Proline metabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 461`	`461`		`Probable proline dehydrogenase 2.`	`PRO_0000308622`

Sequence information

Length: 461 AA [This is the length of the unprocessed precursor]

Molecular weight: 51262 Da [This is the MW of the unprocessed precursor]

CRC64: DF3E394E3AF6356E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLQACRVLRS RAGPSPGSWQ PLSFDGGAFH LKSIGELTRA LLVLRLCAWP PLVTHGLALQ 

        70         80         90        100        110        120 
AWSQRLLGSR LSGALLRASI YGQFVAGETA EEVRSCVLQL QNLGLRPLLA VPTEEEPDSA 

       130        140        150        160        170        180 
VKTGEAWYEG NLSAMLRCVD LSRGLLETPD PTGNALMQLK MTALMSTRLC KQLTSWVRRP 

       190        200        210        220        230        240 
GDSLELSPER LAEAMDSGQD LQVSCLNTEQ TRHLQASLSR LHRVVQHARA QRVRLLVDAE 

       250        260        270        280        290        300 
YTSLNPALSL LVAALATRWN SSGEGGPWVW NTYQAYLKDT YERLRWDAEA ADRAGLAFGV 

       310        320        330        340        350        360 
KLVRGAYLDK ERETARLQGT EDPTQPDYEA TSQSYSRCLE LMLTQVSHRG PMCHLMVASH 

       370        380        390        400        410        420 
NEDSVRQATK RMWELGIPPD GPVCFGQLLG MCDHVSLALG QAGYAVYKSI PYGSLEEVIP 

       430        440        450        460 
YLIRRAQENR SVLRGARREQ ELLSQELRRR LLGRGLRVSP H

A6QQ74 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools