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UniProtKB/Swiss-Prot entry A6QDL6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH1_STAAE
Primary accession number A6QDL6
Secondary accession numbers None
Integrated into Swiss-Prot on July 22, 2008
Sequence was last modified on August 21, 2007 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 13)
Name and origin of the protein
Protein name L-lactate dehydrogenase 1
Synonyms L-LDH 1
EC 1.1.1.27
Gene name
Name: ldh1
OrderedLocusNames: NWMN_0176
From
Staphylococcus aureus (strain Newman) [TaxID: 426430] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.01000-07; PubMed=17951380 [NCBI, ExPASy, EBI, Israel, Japan]
Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
"Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands.";
J. Bacteriol. 190:300-310(2008).
[2]
 FUNCTION IN NITROSATIVE STRESS.
DOI=10.1126/science.1155207; PubMed=18356528 [NCBI, ExPASy, EBI, Israel, Japan]
Richardson A.R., Libby S.J., Fang F.C.;
"A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity.";
Science 319:1672-1676(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AP009351; BAF66448.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001331211.1; -.
3D structure databases
ModBase A6QDL6.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006950; Biological process: response to stress (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS A6QDL6.
ProtoNet A6QDL6.
Genome annotation databases
GeneID 5330031; -.
GenomeReviews AP009351_GR; NWMN_0176.
KEGG sae:NWMN_0176; -.
CMR A6QDL6; NWMN_0176.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein; Stress response.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   317  317     L-lactate dehydrogenase 1. PRO_0000343842
NP_BIND   15    43  29     NAD (By similarity). 
ACT_SITE   179   179        Proton acceptor (By similarity). 
BINDING   92    92        Substrate (By similarity). 
BINDING   124   124        NAD or substrate (By similarity). 
BINDING   155   155        Substrate (By similarity). 
BINDING   232   232        Substrate (By similarity). 
MOD_RES   223   223        Phosphotyrosine (By similarity). 
Sequence information
Length: 317 AA [This is the length of the unprocessed precursor] Molecular weight: 34583 Da [This is the MW of the unprocessed precursor] CRC64: CDDE481269B7DE56 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNKFKGNKVV LIGNGAVGSS YAFSLVNQSI VDELVIIDLD TEKVRGDVMD LKHATPYSPT 

        70         80         90        100        110        120 
TVRVKAGEYS DCHDADLVVI CAGAAQKPGE TRLDLVSKNL KIFKSIVGEV MASKFDGIFL 

       130        140        150        160        170        180 
VATNPVDILA YATWKFSGLP KERVIGSGTI LDSARFRLLL SEAFDVAPRS VDAQIIGEHG 

       190        200        210        220        230        240 
DTELPVWSHA NIAGQPLKTL LEQRPEGKAQ IEQIFVQTRD AAYDIIQAKG ATYYGVAMGL 

       250        260        270        280        290        300 
ARITEAIFRN EDAVLTVSAL LEGEYEEEDV YIGVPAVINR NGIRNVVEIP LNDEEQSKFA 

       310 
HSAKTLKDIM AEAEELK
A6QDL6 in FASTA format

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