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UniProtKB/Swiss-Prot entry A5VAA8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FOLD3_SPHWW
Primary accession number A5VAA8
Secondary accession numbers None
Integrated into Swiss-Prot on June 10, 2008
Sequence was last modified on July 10, 2007 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 16)
Name and origin of the protein
Protein name Bifunctional protein folD 3
Synonyms None
Includes Methylenetetrahydrofolate dehydrogenase
     (EC 1.5.1.5)
Methenyltetrahydrofolate cyclohydrolase
     (EC 3.5.4.9)
Gene name
Name: folD3
OrderedLocusNames: Swit_2872
From
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) [TaxID: 392499] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales; Sphingomonadaceae; Sphingomonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A., Richardson P.;
"Complete sequence of chromosome of Sphingomonas wittichii RW1.";
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000699; ABQ69224.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001263362.1; -.
3D structure databases
ModBase A5VAA8.
Ontologies
GO
GO:0004477; Molecular function: methenyltetrahydrofolate cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004488; Molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0009086; Biological process: methionine biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006164; Biological process: purine nucleotide biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01576; -; 1.
PBIL [Tree]
InterPro IPR016040; NAD(P)-bd.
IPR000672; THF_DHase/CycOHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00763; THF_DHG_CYH; 1.
PF02882; THF_DHG_CYH_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00085; THFDHDRGNASE.
ProDom PD002300; THFDhg/Cyc_hydro; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00766; THF_DHG_CYH_1; 1.
PS00767; THF_DHG_CYH_2; 1.
BLOCKS A5VAA8.
ProtoNet A5VAA8.
Genome annotation databases
GeneID 5196730; -.
GenomeReviews CP000699_GR; Swit_2872.
KEGG swi:Swit_2872; -.
NMPDR fig|392499.4.peg.3032; -.
CMR A5VAA8; Swit_2872.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP; One-carbon metabolism; Oxidoreductase; Purine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   304  304     Bifunctional protein folD 3. PRO_0000340601
Sequence information
Length: 304 AA [This is the length of the unprocessed precursor] Molecular weight: 31569 Da [This is the MW of the unprocessed precursor] CRC64: 644794AB5F564308 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MERVGMNGAE IIDGKAYAAG LRARVATAVP AFRVAAGRAP GLAVVLVGED AASQVYVRSK 

        70         80         90        100        110        120 
HKATVEAGME SFEHRLPATA SETELLALVE RLNADDRVDG ILVQLPLPPH IDEKKVIATI 

       130        140        150        160        170        180 
DPDKDVDGFH VVNAGRLAVG EAGYVPCTPL GCLMLLKDRR GDLSGLEAVV IGRSNIVGKP 

       190        200        210        220        230        240 
MAALLLAENC TVTIAHSRTR DLAEVVRRAD IVVAAVGRPE MVRGDWIRPG ATVIDVGINR 

       250        260        270        280        290        300 
VPGAEPGKTR LVGDVAFAEA AAVAGAITPV PGGVGPMTIA VLLRNTLVAA HRRAGVALPE 


GAIG
A5VAA8 in FASTA format

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