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UniProtKB/Swiss-Prot entry A5F1Z0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_VIBC3
Primary accession number A5F1Z0
Secondary accession numbers None
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on March 18, 2008 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 15)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: VC0395_A0809
From
Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [TaxID: 345073] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Heidelberg J.;
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000627; ABQ21323.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001216759.1; -.
3D structure databases
ModBase A5F1Z0.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS A5F1Z0.
ProtoNet A5F1Z0.
Genome annotation databases
GeneID 5136256; -.
GenomeReviews CP000627_GR; VC0395_A0809.
KEGG vco:VC0395_A0809; -.
CMR A5F1Z0; VC0395_A0809.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   562  562     NAD-dependent malic enzyme. PRO_0000323541
ACT_SITE   101   101        Proton donor (By similarity). 
ACT_SITE   172   172        Proton acceptor (By similarity). 
METAL   243   243        Divalent metal cation (By similarity). 
METAL   244   244        Divalent metal cation (By similarity). 
METAL   267   267        Divalent metal cation (By similarity). 
BINDING   154   154        NAD (By similarity). 
BINDING   267   267        NAD (By similarity). 
BINDING   415   415        NAD (By similarity). 
SITE   267   267  1     Important for activity (By similarity). 
Sequence information
Length: 562 AA [This is the length of the unprocessed precursor] Molecular weight: 62153 Da [This is the MW of the unprocessed precursor] CRC64: 934D1EEF53832130 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNNDKRPLYI SYAGPALLST PLLNKGSAFS AEERASFNLE GLLPEATETI QEQVVRAYQQ 

        70         80         90        100        110        120 
YRGFESDMDK HIYLRNIQDT NETLFYRLVQ NHISEMMPII YTPTVGAACE NFSNIYRRGR 

       130        140        150        160        170        180 
GLFISYANRD RIDDLLNNAA NHNVKVIVVT DGERILGLGD QGIGGMGIPI GKLSLYTACG 

       190        200        210        220        230        240 
GISPAYTLPV VLDVGTNNPQ RLADPMYMGW RHPRITGPDY DNFVEEFMQA VQRRWPDALI 

       250        260        270        280        290        300 
QFEDFAQKNA MPLLERYKNR VCCFNDDIQG TAAVTVGSLL AACKAAGSQL SQQRITFLGA 

       310        320        330        340        350        360 
GSAGCGIAEA IIAQMVSEGI SDEQARSQVY MVDRWGLLEE GMPNLLDFQQ RLVQKKANTQ 

       370        380        390        400        410        420 
HWTTENNGYS LHDVIRNAKP TVLVGVSGAP GLFSEEIIKE MHQHCPRPIV FPLSNPTSRV 

       430        440        450        460        470        480 
EALPSDIIRW TNGEALVATG SPFDPVLHEG KTYPIVQCNN SYIFPGIGLG VLAANARRVT 

       490        500        510        520        530        540 
DEMLMESSRA LASCSPLAIN GHGPLLPPLE SIHSVSKKIA FAVAKKAIEQ GVAPEVTDEA 

       550        560 
LEASIEQHFW QPVYRRYKRT AF
A5F1Z0 in FASTA format

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