[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP695).
TISSUE=Brain;
DOI=10.1038/325733a0; PubMed=2881207 [NCBI, ExPASy, EBI, Israel, Japan]
Kang J.,
Lemaire H.-G.,
Unterbeck A.,
Salbaum J.M.,
Masters C.L.,
Grzeschik K.-H.,
Multhaup G.,
Beyreuther K.,
Mueller-Hill B.;
"The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.";
Nature 325:733-736(1987).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP751).
TISSUE=Brain;
DOI=10.1038/331525a0; PubMed=2893289 [NCBI, ExPASy, EBI, Israel, Japan]
Ponte P.,
Gonzalez-Dewhitt P.,
Schilling J.,
Miller J.,
Hsu D.,
Greenberg B.,
Davis K.,
Wallace W.,
Lieberburg I.,
Fuller F.,
Cordell B.;
"A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.";
Nature 331:525-527(1988).
|
[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM APP695).
DOI=10.1093/nar/17.2.517; PubMed=2783775 [NCBI, ExPASy, EBI, Israel, Japan]
Lemaire H.-G.,
Salbaum J.M.,
Multhaup G.,
Kang J.,
Bayney R.M.,
Unterbeck A.,
Beyreuther K.,
Mueller-Hill B.;
"The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.";
Nucleic Acids Res. 17:517-522(1989).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM APP770).
DOI=10.1016/0378-1119(90)90310-N; PubMed=2110105 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshikai S.,
Sasaki H.,
Doh-ura K.,
Furuya H.,
Sakaki Y.;
"Genomic organization of the human amyloid beta-protein precursor gene.";
Gene 87:257-263(1990).
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[5]
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ERRATUM.
DOI=10.1016/0378-1119(91)90093-Q; PubMed=1908403 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshikai S.,
Sasaki H.,
Doh-ura K.,
Furuya H.,
Sakaki Y.;
Gene 102:291-292(1991).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM L-APP733).
TISSUE=Leukocyte;
PubMed=1587857 [NCBI, ExPASy, EBI, Israel, Japan]
Koenig G.,
Moenning U.,
Czech C.,
Prior R.,
Banati R.,
Schreiter-Gasser U.,
Bauer J.,
Masters C.L.,
Beyreuther K.;
"Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.";
J. Biol. Chem. 267:10804-10809(1992).
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM APP770).
DOI=10.1093/nar/25.9.1802; PubMed=9108164 [NCBI, ExPASy, EBI, Israel, Japan]
Hattori M.,
Tsukahara F.,
Furuhata Y.,
Tanahashi H.,
Hirose M.,
Saito M.,
Tsukuni S.,
Sakaki Y.;
"A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus.";
Nucleic Acids Res. 25:1802-1808(1997).
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[8]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP639), AND TISSUE SPECIFICITY.
TISSUE=Brain;
DOI=10.1046/j.1460-9568.2003.02731.x; PubMed=12859342 [NCBI, ExPASy, EBI, Israel, Japan]
Tang K.,
Wang C.,
Shen C.,
Sheng S.,
Ravid R.,
Jing N.;
"Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.";
Eur. J. Neurosci. 18:102-108(2003).
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[9]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-501.
Livingston R.J.,
Rieder M.J.,
Rajkumar N.,
Downing T.K.,
Olson A.N.,
Nguyen C.P.,
Gildersleeve H.,
Cassidy C.M.,
Johnson E.J.,
Swanson J.E.,
McFarland I.,
Yool B.,
Park C.,
Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS APP305 AND APP751).
TISSUE=Eye, and Pancreas;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[11]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1-10.
TISSUE=Liver;
DOI=10.1093/nar/16.19.9351; PubMed=3140222 [NCBI, ExPASy, EBI, Israel, Japan]
Schon E.A.,
Mita S.,
Sadlock J.,
Herbert J.;
"A cDNA specifying the human amyloid beta precursor protein (ABPP) encodes a 95-kDa polypeptide.";
Nucleic Acids Res. 16:9351-9351(1988).
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[12]
|
ERRATUM, AND SEQUENCE REVISION.
Schon E.A.,
Mita S.,
Sadlock J.,
Herbert J.;
Nucleic Acids Res. 16:11402-11402(1988).
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[13]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
DOI=10.1016/0006-291X(89)92437-6; PubMed=2538123 [NCBI, ExPASy, EBI, Israel, Japan]
La Fauci G.,
Lahiri D.K.,
Salton S.R.,
Robakis N.K.;
"Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene.";
Biochem. Biophys. Res. Commun. 159:297-304(1989).
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[14]
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PROTEIN SEQUENCE OF 18-50.
TISSUE=Fibroblast;
PubMed=3597385 [NCBI, ExPASy, EBI, Israel, Japan]
van Nostrand W.E.,
Cunningham D.D.;
"Purification of protease nexin II from human fibroblasts.";
J. Biol. Chem. 262:8508-8514(1987).
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[15]
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PROTEIN SEQUENCE OF 18-40.
TISSUE=Platelet;
DOI=10.1038/nbt810; PubMed=12665801 [NCBI, ExPASy, EBI, Israel, Japan]
Gevaert K.,
Goethals M.,
Martens L.,
Van Damme J.,
Staes A.,
Thomas G.R.,
Vandekerckhove J.;
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.";
Nat. Biotechnol. 21:566-569(2003).
|
[16]
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PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP751).
TISSUE=Brain;
PubMed=2569763 [NCBI, ExPASy, EBI, Israel, Japan]
de Sauvage F.,
Octave J.-N.;
"A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein.";
Science 245:651-653(1989).
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[17]
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PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP695).
TISSUE=Brain;
PubMed=3035574 [NCBI, ExPASy, EBI, Israel, Japan]
Robakis N.K.,
Ramakrishna N.,
Wolfe G.,
Wisniewski H.M.;
"Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.";
Proc. Natl. Acad. Sci. U.S.A. 84:4190-4194(1987).
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[18]
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NUCLEOTIDE SEQUENCE [MRNA] OF 286-366.
DOI=10.1038/331528a0; PubMed=2893290 [NCBI, ExPASy, EBI, Israel, Japan]
Tanzi R.E.,
McClatchey A.I.,
Lamperti E.D.,
Villa-Komaroff L.,
Gusella J.F.,
Neve R.L.;
"Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.";
Nature 331:528-530(1988).
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[19]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 287-367.
DOI=10.1038/331530a0; PubMed=2893291 [NCBI, ExPASy, EBI, Israel, Japan]
Kitaguchi N.,
Takahashi Y.,
Tokushima Y.,
Shiojiri S.,
Ito H.;
"Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity.";
Nature 331:530-532(1988).
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[20]
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NUCLEOTIDE SEQUENCE [MRNA] OF 507-770.
TISSUE=Brain cortex;
PubMed=2893379 [NCBI, ExPASy, EBI, Israel, Japan]
Zain S.B.,
Salim M.,
Chou W.G.,
Sajdel-Sulkowska E.M.,
Majocha R.E.,
Marotta C.A.;
"Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.";
Proc. Natl. Acad. Sci. U.S.A. 85:929-933(1988).
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[21]
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PROTEIN SEQUENCE OF 523-555, AND DOMAIN COLLAGEN-BINDING.
DOI=10.1074/jbc.271.3.1613; PubMed=8576160 [NCBI, ExPASy, EBI, Israel, Japan]
Beher D.,
Hesse L.,
Masters C.L.,
Multhaup G.;
"Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.";
J. Biol. Chem. 271:1613-1620(1996).
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[22]
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NUCLEOTIDE SEQUENCE [MRNA] OF 655-737, AND VARIANTS AD GLY-717; ILE-717 AND PHE-717.
DOI=10.1006/bbrc.1993.1386; PubMed=8476439 [NCBI, ExPASy, EBI, Israel, Japan]
Denman R.B.,
Rosenzcwaig R.,
Miller D.L.;
"A system for studying the effect(s) of familial Alzheimer disease mutations on the processing of the beta-amyloid peptide precursor.";
Biochem. Biophys. Res. Commun. 192:96-103(1993).
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[23]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 656-737.
DOI=10.1016/0006-291X(89)91112-1; PubMed=2675837 [NCBI, ExPASy, EBI, Israel, Japan]
Johnstone E.M.,
Chaney M.O.,
Moore R.E.,
Ward K.E.,
Norris F.H.,
Little S.P.;
"Alzheimer's disease amyloid peptide is encoded by two exons and shows similarity to soybean trypsin inhibitor.";
Biochem. Biophys. Res. Commun. 163:1248-1255(1989).
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[24]
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PROTEIN SEQUENCE OF 672-701 AND 707-713.
PubMed=8109908 [NCBI, ExPASy, EBI, Israel, Japan]
Wisniewski T.,
Lalowski M.,
Levy E.,
Marques M.R.F.,
Frangione B.;
"The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient.";
Ann. Neurol. 35:245-246(1994).
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[25]
|
PROTEIN SEQUENCE OF 672-701.
TISSUE=Cerebrospinal fluid;
PubMed=8229004 [NCBI, ExPASy, EBI, Israel, Japan]
Vigo-Pelfrey C.,
Lee D.,
Keim P.,
Lieberburg I.,
Schenk D.B.;
"Characterization of beta-amyloid peptide from human cerebrospinal fluid.";
J. Neurochem. 61:1965-1968(1993).
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[26]
|
PROTEIN SEQUENCE OF 672-681.
TISSUE=Brain cortex;
PubMed=3312495 [NCBI, ExPASy, EBI, Israel, Japan]
Pardridge W.M.,
Vinters H.V.,
Yang J.,
Eisenberg J.,
Choi T.B.,
Tourtellotte W.W.,
Huebner V.,
Shively J.E.;
"Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4,200-dalton peptide isolated from cortical microvessels.";
J. Neurochem. 49:1394-1401(1987).
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[27]
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PROTEIN SEQUENCE OF 672-713.
TISSUE=Blood vessel;
PubMed=8248178 [NCBI, ExPASy, EBI, Israel, Japan]
Roher A.E.,
Lowenson J.D.,
Clarke S.,
Woods A.S.,
Cotter R.J.,
Gowing E.,
Ball M.J.;
"Beta-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.";
Proc. Natl. Acad. Sci. U.S.A. 90:10836-10840(1993).
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[28]
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NUCLEOTIDE SEQUENCE [MRNA] OF 674-770.
TISSUE=Brain;
PubMed=3810169 [NCBI, ExPASy, EBI, Israel, Japan]
Goldgaber D.,
Lerman M.I.,
McBride O.W.,
Saffiotti U.,
Gajdusek D.C.;
"Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.";
Science 235:877-880(1987).
|
[29]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 674-703.
TISSUE=Fetal brain;
PubMed=2949367 [NCBI, ExPASy, EBI, Israel, Japan]
Tanzi R.E.,
Gusella J.F.,
Watkins P.C.,
Bruns G.A.,
St George-Hyslop P.H.,
Van Keuren M.L.,
Patterson D.,
Pagan S.,
Kurnit D.M.,
Neve R.L.;
"Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.";
Science 235:880-884(1987).
|
[30]
|
CHARACTERIZATION OF L-APP733, AND MUTAGENESIS OF SER-656.
DOI=10.1074/jbc.270.18.10388; PubMed=7737970 [NCBI, ExPASy, EBI, Israel, Japan]
Pangalos M.N.,
Efthimiopoulos S.,
Shioi J.,
Robakis N.K.;
"The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene.";
J. Biol. Chem. 270:10388-10391(1995).
|
[31]
|
FUNCTION OF BETA-AMYLOID PEPTIDE AS LIPID PEROXIDATION INHIBITOR, AND MUTAGENESIS OF MET-706.
DOI=10.1006/bbrc.1997.6547; PubMed=9168929 [NCBI, ExPASy, EBI, Israel, Japan]
Walter M.F.,
Mason P.E.,
Mason R.P.;
"Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions.";
Biochem. Biophys. Res. Commun. 233:760-764(1997).
|
[32]
|
REVIEW ON FUNCTION OF BETA-AMYLOID AS ANTIOXIDANT.
DOI=10.1023/A:1012629603390; PubMed=11775062 [NCBI, ExPASy, EBI, Israel, Japan]
Kontush A.;
"Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins.";
Cell. Mol. Neurobiol. 21:299-315(2001).
|
[33]
|
IDENTITY OF APP WITH NEXIN-II.
DOI=10.1038/341144a0; PubMed=2506449 [NCBI, ExPASy, EBI, Israel, Japan]
Oltersdorf T.,
Fritz L.C.,
Schenk D.B.,
Lieberburg I.,
Johnson-Wood K.L.,
Beattie E.C.,
Ward P.J.,
Blacher R.W.,
Dovey H.F.,
Sinha S.;
"The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.";
Nature 341:144-147(1989).
|
[34]
|
PROTEASE-SPECIFICITY OF INHIBITOR DOMAIN.
DOI=10.1016/0006-291X(90)92084-D; PubMed=1969731 [NCBI, ExPASy, EBI, Israel, Japan]
Kido H.,
Fukutomi A.,
Schilling J.,
Wang Y.,
Cordell B.,
Katunuma N.;
"Protease-specificity of Kunitz inhibitor domain of Alzheimer's disease amyloid protein precursor.";
Biochem. Biophys. Res. Commun. 167:716-721(1990).
|
[35]
|
EXTRACELLULAR ZINC-BINDING DOMAIN.
PubMed=8344894 [NCBI, ExPASy, EBI, Israel, Japan]
Bush A.I.,
Multhaup G.,
Moir R.D.,
Williamson T.G.,
Small D.H.,
Rumble B.,
Pollwein P.,
Beyreuther K.,
Masters C.L.;
"A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.";
J. Biol. Chem. 268:16109-16112(1993).
|
[36]
|
COMPLEX WITH G(O).
DOI=10.1038/362075a0; PubMed=8446172 [NCBI, ExPASy, EBI, Israel, Japan]
Nishimoto I.,
Okamoto T.,
Matsuura Y.,
Takahashi S.,
Okamoto T.,
Murayama Y.,
Ogata E.;
"Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o).";
Nature 362:75-79(1993).
|
[37]
|
EXTRACELLULAR COPPER-BINDING DOMAIN, AND MUTAGENESIS OF HIS-137; MET-141; CYS-144; HIS-147 AND HIS-151.
DOI=10.1016/0014-5793(94)00658-X; PubMed=7913895 [NCBI, ExPASy, EBI, Israel, Japan]
Hesse L.,
Beher D.,
Masters C.L.,
Multhaup G.;
"The beta A4 amyloid precursor protein binding to copper.";
FEBS Lett. 349:109-116(1994).
|
[38]
|
N-TERMINAL HEPARIN-BINDING DOMAIN, AND MUTAGENESIS OF 99-LYS--ARG-102.
PubMed=8158260 [NCBI, ExPASy, EBI, Israel, Japan]
Small D.H.,
Nurcombe V.,
Reed G.,
Clarris H.,
Moir R.,
Beyreuther K.,
Masters C.L.;
"A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth.";
J. Neurosci. 14:2117-2127(1994).
|
[39]
|
MUTAGENESIS OF VAL-717.
DOI=10.1006/bbrc.1996.1577; PubMed=8886002 [NCBI, ExPASy, EBI, Israel, Japan]
Maruyama K.,
Tomita T.,
Shinozaki K.,
Kume H.,
Asada H.,
Saido T.C.,
Ishiura S.,
Iwatsubo T.,
Obata K.;
"Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).";
Biochem. Biophys. Res. Commun. 227:730-735(1996).
|
[40]
|
INTERACTION WITH APP-BP1.
DOI=10.1074/jbc.271.19.11339; PubMed=8626687 [NCBI, ExPASy, EBI, Israel, Japan]
Chow N.,
Korenberg J.R.,
Chen X.-N.,
Neve R.L.;
"APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.";
J. Biol. Chem. 271:11339-11346(1996).
|
[41]
|
INTERACTION WITH APBA1 AND APBB1, AND MUTAGENESIS OF TYR-728; TYR-757; ASN-759 AND TYR-762.
PubMed=8887653 [NCBI, ExPASy, EBI, Israel, Japan]
Borg J.-P.,
Ooi J.,
Levy E.,
Margolis B.;
"The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.";
Mol. Cell. Biol. 16:6229-6241(1996).
|
[42]
|
INTERACTION WITH APBB2.
DOI=10.1073/pnas.93.20.10832; PubMed=8855266 [NCBI, ExPASy, EBI, Israel, Japan]
Guenette S.Y.,
Chen J.,
Jondro P.D.,
Tanzi R.E.;
"Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.";
Proc. Natl. Acad. Sci. U.S.A. 93:10832-10837(1996).
|
[43]
|
HEPARIN-BINDING DOMAINS.
DOI=10.1016/S0014-5793(97)01146-0; PubMed=9357988 [NCBI, ExPASy, EBI, Israel, Japan]
Mok S.S.,
Sberna G.,
Heffernan D.,
Cappai R.,
Galatis D.,
Clarris H.J.,
Sawyer W.H.,
Beyreuther K.,
Masters C.L.,
Small D.H.;
"Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease.";
FEBS Lett. 415:303-307(1997).
|
[44]
|
INTERACTION OF BETA-AMYLOID PEPTIDE WITH HADH2.
TISSUE=Brain;
DOI=10.1038/39522; PubMed=9338779 [NCBI, ExPASy, EBI, Israel, Japan]
Yan S.D.,
Fu J.,
Soto C.,
Chen X.,
Zhu H.,
Al-Mohanna F.,
Collinson K.,
Zhu A.,
Stern E.,
Saido T.,
Tohyama M.,
Ogawa S.,
Roher A.,
Stern D.;
"An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.";
Nature 389:689-695(1997).
|
[45]
|
INTERACTION WITH APPBP2, AND MUTAGENESIS OF TYR-728.
DOI=10.1073/pnas.95.25.14745; PubMed=9843960 [NCBI, ExPASy, EBI, Israel, Japan]
Zheng P.,
Eastman J.,
Vande Pol S.,
Pimplikar S.W.;
"PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein.";
Proc. Natl. Acad. Sci. U.S.A. 95:14745-14750(1998).
|
[46]
|
BETA-AMYLOID ZINC-BINDING, AND MUTAGENESIS OF ARG-676; TYR-681 AND HIS-684.
DOI=10.1021/bi990205o; PubMed=10413512 [NCBI, ExPASy, EBI, Israel, Japan]
Liu S.T.,
Howlett G.,
Barrow C.J.;
"Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease.";
Biochemistry 38:9373-9378(1999).
|
[47]
|
IMPORTANCE OF MET-706 IN FREE RADICAL OXIDATIVE STRESS, AND MUTAGENESIS OF MET-706.
DOI=10.1016/S0361-9230(99)00093-3; PubMed=10535332 [NCBI, ExPASy, EBI, Israel, Japan]
Varadarajan S.,
Yatin S.,
Kanski J.,
Jahanshahi F.,
Butterfield D.A.;
"Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.";
Brain Res. Bull. 50:133-141(1999).
|
[48]
|
INTERACTION WITH APBA2.
DOI=10.1074/jbc.274.4.2243; PubMed=9890987 [NCBI, ExPASy, EBI, Israel, Japan]
Tomita S.,
Ozaki T.,
Taru H.,
Oguchi S.,
Takeda S.,
Yagi Y.,
Sakiyama S.,
Kirino Y.,
Suzuki T.;
"Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.";
J. Biol. Chem. 274:2243-2254(1999).
|
[49]
|
ENDOCYTOSIS SIGNAL, AND MUTAGENESIS OF TYR-728; GLY-756; TYR-757; ASN-759; PRO-760 AND TYR-762.
DOI=10.1074/jbc.274.27.18851; PubMed=10383380 [NCBI, ExPASy, EBI, Israel, Japan]
Perez R.G.,
Soriano S.,
Hayes J.D.,
Ostaszewski B.,
Xia W.,
Selkoe D.J.,
Chen X.,
Stokin G.B.,
Koo E.H.;
"Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.";
J. Biol. Chem. 274:18851-18856(1999).
|
[50]
|
IMPORTANCE OF CYS-144 IN COPPER REDUCTION, AND MUTAGENESIS OF CYS-144 AND 147-HIS--HIS-149.
PubMed=10461923 [NCBI, ExPASy, EBI, Israel, Japan]
Ruiz F.H.,
Gonzalez M.,
Bodini M.,
Opazo C.,
Inestrosa N.C.;
"Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein.";
J. Neurochem. 73:1288-1292(1999).
|
[51]
|
INTERACTION OF BETA-AMYLOID WITH APOE.
DOI=10.1042/0264-6021:3480359; PubMed=10816430 [NCBI, ExPASy, EBI, Israel, Japan]
Tokuda T.,
Calero M.,
Matsubara E.,
Vidal R.,
Kumar A.,
Permanne B.,
Zlokovic B.,
Smith J.D.,
Ladu M.J.,
Rostagno A.,
Frangione B.,
Ghiso J.;
"Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.";
Biochem. J. 348:359-365(2000).
|
[52]
|
INTERACTION OF BETA-APP42 WITH CHRNA7.
DOI=10.1074/jbc.275.8.5626; PubMed=10681545 [NCBI, ExPASy, EBI, Israel, Japan]
Wang H.-Y.,
Lee D.H.S.,
D'Andrea M.R.,
Peterson P.A.,
Shank R.P.,
Reitz A.B.;
"Beta-amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.";
J. Biol. Chem. 275:5626-5632(2000).
|
[53]
|
IDENTIFICATION OF GAMMA-CTFS BY MASS SPECTROMETRY, AND MUTAGENESIS OF ASP-739.
PubMed=12214090 [NCBI, ExPASy, EBI, Israel, Japan]
Passer B.,
Pellegrini L.,
Russo C.,
Siegel R.M.,
Lenardo M.J.,
Schettini G.,
Bachmann M.,
Tabaton M.,
D'Adamio L.;
"Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.";
J. Alzheimers Dis. 2:289-301(2000).
|
[54]
|
INTERACTION WITH FPRL1.
DOI=10.1096/fj.01-0251com; PubMed=11689470 [NCBI, ExPASy, EBI, Israel, Japan]
Yazawa H.,
Yu Z.-X.,
Takeda K.,
Le Y.,
Gong W.,
Ferrans V.J.,
Oppenheim J.J.,
Li C.C.H.,
Wang J.M.;
"Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.";
FASEB J. 15:2454-2462(2001).
|
[55]
|
INTERACTION WITH BBP.
DOI=10.1074/jbc.M011161200; PubMed=11278849 [NCBI, ExPASy, EBI, Israel, Japan]
Kajkowski E.M.,
Lo C.F.,
Ning X.,
Walker S.,
Sofia H.J.,
Wang W.,
Edris W.,
Chanda P.,
Wagner E.,
Vile S.,
Ryan K.,
McHendry-Rinde B.,
Smith S.C.,
Wood A.,
Rhodes K.J.,
Kennedy J.D.,
Bard J.,
Jacobsen J.S.,
Ozenberger B.A.;
"Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module.";
J. Biol. Chem. 276:18748-18756(2001).
|
[56]
|
BETA-AMYLOID COPPER AND ZINC-BINDING.
DOI=10.1074/jbc.M100175200; PubMed=11274207 [NCBI, ExPASy, EBI, Israel, Japan]
Curtain C.C.,
Ali F.,
Volitakis I.,
Cherny R.A.,
Norton R.S.,
Beyreuther K.,
Barrow C.J.,
Masters C.L.,
Bush A.I.,
Barnham K.J.;
"Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered structure containing superoxide dismutase-like subunits.";
J. Biol. Chem. 276:20466-20473(2001).
|
[57]
|
SUBUNIT.
DOI=10.1074/jbc.M105410200; PubMed=11438549 [NCBI, ExPASy, EBI, Israel, Japan]
Scheuermann S.,
Hambsch B.,
Hesse L.,
Stumm J.,
Schmidt C.,
Beher D.,
Bayer T.A.,
Beyreuther K.,
Multhaup G.;
"Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.";
J. Biol. Chem. 276:33923-33929(2001).
|
[58]
|
INTERACTION WITH APBB1, FUNCTION, AND SUBCELLULAR LOCATION.
DOI=10.1074/jbc.C100447200; PubMed=11544248 [NCBI, ExPASy, EBI, Israel, Japan]
Kimberly W.T.,
Zheng J.B.,
Guenette S.Y.,
Selkoe D.J.;
"The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.";
J. Biol. Chem. 276:40288-40292(2001).
|
[59]
|
INTERACTION WITH FBLN1.
PubMed=11238726 [NCBI, ExPASy, EBI, Israel, Japan]
Ohsawa I.,
Takamura C.,
Kohsaka S.;
"Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function.";
J. Neurochem. 76:1411-1420(2001).
|
[60]
|
INTERACTION WITH MAPT, AND FUNCTION.
DOI=10.1016/S0014-5793(02)02376-1; PubMed=11943163 [NCBI, ExPASy, EBI, Israel, Japan]
Rank K.B.,
Pauley A.M.,
Bhattacharya K.,
Wang Z.,
Evans D.B.,
Fleck T.J.,
Johnston J.A.,
Sharma S.K.;
"Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II.";
FEBS Lett. 514:263-268(2002).
|
[61]
|
INTERACTION WITH MAPK8IP1, AND MUTAGENESIS OF TYR-757.
DOI=10.1074/jbc.M108357200; PubMed=11724784 [NCBI, ExPASy, EBI, Israel, Japan]
Scheinfeld M.H.,
Roncarati R.,
Vito P.,
Lopez P.A.,
Abdallah M.,
D'Adamio L.;
"Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).";
J. Biol. Chem. 277:3767-3775(2002).
|
[62]
|
COPPER-MEDIATED LIPID PEROXIDATION, AND MUTAGENESIS OF HIS-147 AND HIS-151.
PubMed=11784781 [NCBI, ExPASy, EBI, Israel, Japan]
White A.R.,
Multhaup G.,
Galatis D.,
McKinstry W.J.,
Parker M.W.,
Pipkorn R.,
Beyreuther K.,
Masters C.L.,
Cappai R.;
"Contrasting species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.";
J. Neurosci. 22:365-376(2002).
|
[63]
|
REVIEW ON ZINC-BINDING.
DOI=10.1073/pnas.122249699; PubMed=12032279 [NCBI, ExPASy, EBI, Israel, Japan]
Bush A.I.,
Tanzi R.E.;
"The galvanization of beta-amyloid in Alzheimer's disease.";
Proc. Natl. Acad. Sci. U.S.A. 99:7317-7319(2002).
|
[64]
|
INTERACTION WITH ANKS1B.
DOI=10.1074/jbc.M405329200; PubMed=15347684 [NCBI, ExPASy, EBI, Israel, Japan]
Ghersi E.,
Noviello C.,
D'Adamio L.;
"Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.";
J. Biol. Chem. 279:49105-49112(2004).
|
[65]
|
PHOSPHORYLATION AT THR-743.
PubMed=8131745 [NCBI, ExPASy, EBI, Israel, Japan]
Suzuki T.,
Oishi M.,
Marshak D.R.,
Czernik A.J.,
Nairn A.C.,
Greengard P.;
"Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.";
EMBO J. 13:1114-1122(1994).
|
[66]
|
PHOSPHORYLATION BY CASEIN KINASES, AND MUTAGENESIS OF SER-198 AND SER-206.
DOI=10.1074/jbc.272.3.1896; PubMed=8999878 [NCBI, ExPASy, EBI, Israel, Japan]
Walter J.,
Capell A.,
Hung A.Y.,
Langen H.,
Schnoelzer M.,
Thinakaran G.,
Sisodia S.S.,
Selkoe D.J.,
Haass C.;
"Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.";
J. Biol. Chem. 272:1896-1903(1997).
|
[67]
|
COPPER-BINDING, AND DISULFIDE BOND FORMATION.
DOI=10.1021/bi980022m; PubMed=9585534 [NCBI, ExPASy, EBI, Israel, Japan]
Multhaup G.,
Ruppert T.,
Schlicksupp A.,
Hesse L.,
Bill E.,
Pipkorn R.,
Masters C.L.,
Beyreuther K.;
"Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.";
Biochemistry 37:7224-7230(1998).
|
[68]
|
CLEAVAGE BY CASPASES, AND MUTAGENESIS OF ASP-739.
DOI=10.1016/S0092-8674(00)80748-5; PubMed=10319819 [NCBI, ExPASy, EBI, Israel, Japan]
Gervais F.G.,
Xu D.,
Robertson G.S.,
Vaillancourt J.P.,
Zhu Y.,
Huang J.,
LeBlanc A.,
Smith D.,
Rigby M.,
Shearman M.S.,
Clarke E.E.,
Zheng H.,
van der Ploeg L.H.T.,
Ruffolo S.C.,
Thornberry N.A.,
Xanthoudakis S.,
Zamboni R.J.,
Roy S.,
Nicholson D.W.;
"Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.";
Cell 97:395-406(1999).
|
[69]
|
PHOSPHORYLATION, AND MUTAGENESIS OF THR-743.
PubMed=10341243 [NCBI, ExPASy, EBI, Israel, Japan]
Ando K.,
Oishi M.,
Takeda S.,
Iijima K.,
Isohara T.,
Nairn A.C.,
Kirino Y.,
Greengard P.,
Suzuki T.;
"Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.";
J. Neurosci. 19:4421-4427(1999).
|
[70]
|
CHARACTERIZATION OF CASEIN KINASE PHOSPHORYLATION, AND MUTAGENESIS OF SER-198 AND SER-206.
DOI=10.1074/jbc.M002850200; PubMed=10806211 [NCBI, ExPASy, EBI, Israel, Japan]
Walter J.,
Schindzielorz A.,
Hartung B.,
Haass C.;
"Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2.";
J. Biol. Chem. 275:23523-23529(2000).
|
[71]
|
CLEAVAGE BY CASPASES, AND MUTAGENESIS OF ASP-739.
DOI=10.1038/74656; PubMed=10742146 [NCBI, ExPASy, EBI, Israel, Japan]
Lu D.C.,
Rabizadeh S.,
Chandra S.,
Shayya R.F.,
Ellerby L.M.,
Ye X.,
Salvesen G.S.,
Koo E.H.,
Bredesen D.E.;
"A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.";
Nat. Med. 6:397-404(2000).
|
[72]
|
PHOSPHORYLATION, COMPLEX WITH APBB1, AND MUTAGENESIS OF THR-743.
DOI=10.1074/jbc.M104059200; PubMed=11517218 [NCBI, ExPASy, EBI, Israel, Japan]
Ando K.,
Iijima K.,
Elliott J.I.,
Kirino Y.,
Suzuki T.;
"Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.";
J. Biol. Chem. 276:40353-40361(2001).
|
[73]
|
PHOSPHORYLATION BY MAPK10, AND MUTAGENESIS OF THR-743.
PubMed=11146006 [NCBI, ExPASy, EBI, Israel, Japan]
Standen C.L.,
Brownlees J.,
Grierson A.J.,
Kesavapany S.,
Lau K.-F.,
McLoughlin D.M.,
Miller C.C.J.;
"Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).";
J. Neurochem. 76:316-320(2001).
|
[74]
|
CLEAVAGE AT LEU-720.
DOI=10.1021/bi015794o; PubMed=11851430 [NCBI, ExPASy, EBI, Israel, Japan]
Weidemann A.,
Eggert S.,
Reinhard F.B.M.,
Vogel M.,
Paliga K.,
Baier G.,
Masters C.L.,
Beyreuther K.,
Evin G.;
"A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.";
Biochemistry 41:2825-2835(2002).
|
[75]
|
PHOSPHORYLATION AT TYROSINE RESIDUES, INTERACTION WITH SHC1, AND MUTAGENESIS OF THR-743 AND TYR-757.
DOI=10.1074/jbc.M110286200; PubMed=11877420 [NCBI, ExPASy, EBI, Israel, Japan]
Tarr P.E.,
Roncarati R.,
Pelicci G.,
Pelicci P.G.,
D'Adamio L.;
"Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.";
J. Biol. Chem. 277:16798-16804(2002).
|
[76]
|
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-542, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan]
Liu T.,
Qian W.-J.,
Gritsenko M.A.,
Camp D.G. II,
Monroe M.E.,
Moore R.J.,
Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
|
[77]
|
SIGNAL SEQUENCE CLEAVAGE SITE, AND TOPOLOGY.
PubMed=2900137 [NCBI, ExPASy, EBI, Israel, Japan]
Dyrks T.,
Weidemann A.,
Multhaup G.,
Salbaum J.M.,
Lemaire H.-G.,
Kang J.,
Mueller-Hill B.,
Masters C.L.,
Beyreuther K.;
"Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.";
EMBO J. 7:949-957(1988).
|
[78]
|
REVIEW.
DOI=10.1146/annurev.cellbio.18.020402.142302; PubMed=12142279 [NCBI, ExPASy, EBI, Israel, Japan]
Annaert W.,
De Strooper B.;
"A cell biological perspective on Alzheimer's disease.";
Annu. Rev. Cell Dev. Biol. 18:25-51(2002).
|
[79]
|
X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 287-344.
DOI=10.1021/bi00495a002; PubMed=2125487 [NCBI, ExPASy, EBI, Israel, Japan]
Hynes T.R.,
Randal M.,
Kennedy L.A.,
Eigenbrot C.,
Kossiakof A.A.;
"X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.";
Biochemistry 29:10018-10022(1990).
|
[80]
|
STRUCTURE BY NMR OF 289-344.
DOI=10.1021/bi00107a015; PubMed=1718421 [NCBI, ExPASy, EBI, Israel, Japan]
Heald S.L.,
Tilton R.F. Jr.,
Hammond L.S.,
Lee A.,
Bayney R.M.,
Kamarck M.E.,
Ramabhadran T.V.,
Dreyer R.N.,
Davis G.,
Unterbeck A.,
Tamburini P.P.;
"Sequential NMR resonance assignment and structure determination of the Kunitz-type inhibitor domain of the Alzheimer's beta-amyloid precursor protein.";
Biochemistry 30:10467-10478(1991).
|
[81]
|
STRUCTURE BY NMR OF 672-699.
DOI=10.1021/bi00191a006; PubMed=7516706 [NCBI, ExPASy, EBI, Israel, Japan]
Talafous J.,
Marcinowski K.J.,
Klopman G.,
Zagorski M.G.;
"Solution structure of residues 1-28 of the amyloid beta-peptide.";
Biochemistry 33:7788-7796(1994).
|
[82]
|
STRUCTURE BY NMR OF 672-711.
PubMed=7588758 [NCBI, ExPASy, EBI, Israel, Japan]
Sticht H.,
Bayer P.,
Willbold D.,
Dames S.,
Hilbich C.,
Beyreuther K.,
Frank R.W.,
Rosch P.;
"Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease.";
Eur. J. Biochem. 233:293-298(1995).
|
[83]
|
STRUCTURE BY NMR OF 696-706.
DOI=10.1021/bi961598j; PubMed=8973180 [NCBI, ExPASy, EBI, Israel, Japan]
Kohno T.,
Kobayashi K.,
Maeda T.,
Sato K.,
Takashima A.;
"Three-dimensional structures of the amyloid beta peptide (25-35) in membrane-mimicking environment.";
Biochemistry 35:16094-16104(1996).
|
[84]
|
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF KUNITZ DOMAIN IN COMPLEX WITH CHYMOTRYPSIN; TRYPSIN AND BASIC PANCREATIC TRYPSIN INHIBITOR.
PubMed=9300481 [NCBI, ExPASy, EBI, Israel, Japan]
Scheidig A.J.,
Hynes T.R.,
Pelletier L.A.,
Wells J.A.,
Kossiakoff A.A.;
"Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.";
Protein Sci. 6:1806-1824(1997).
|
[85]
|
STRUCTURE BY NMR OF 672-711.
DOI=10.1021/bi972979f; PubMed=9693002 [NCBI, ExPASy, EBI, Israel, Japan]
Coles M.,
Bicknell W.,
Watson A.A.,
Fairlie D.P.,
Craik D.J.;
"Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?";
Biochemistry 37:11064-11077(1998).
|
[86]
|
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 28-123.
DOI=10.1038/7562; PubMed=10201399 [NCBI, ExPASy, EBI, Israel, Japan]
Rossjohn J.,
Cappai R.,
Feil S.C.,
Henry A.,
McKinstry W.J.,
Galatis D.,
Hesse L.,
Multhaup G.,
Beyreuther K.,
Masters C.L.,
Parker M.W.;
"Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.";
Nat. Struct. Biol. 6:327-331(1999).
|
[87]
|
STRUCTURE OF HCHWAD VARIANTS.
DOI=10.1074/jbc.M003154200; PubMed=10821838 [NCBI, ExPASy, EBI, Israel, Japan]
Miravalle L.,
Tokuda T.,
Chiarle R.,
Giaccone G.,
Bugiani O.,
Tagliavini F.,
Frangione B.,
Ghiso J.;
"Substitutions at codon 22 of Alzheimer's Abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.";
J. Biol. Chem. 275:27110-27116(2000).
|
[88]
|
STRUCTURE BY NMR OF 681-706.
DOI=10.1006/jsbi.2000.4288; PubMed=10940221 [NCBI, ExPASy, EBI, Israel, | |
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