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HAMAP: Pseudomonas aeruginosa (strain UCBPP-PA14) complete proteome

General information

Species:  Pseudomonas aeruginosa (strain UCBPP-PA14)
Species code: PSEAB
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas (TaxID: 208963) [NEWT/ NCBI]
Description: Pseudomonas aeruginosa is an important soil bacterium, with a complex metabolism capable of degrading polycyclic aromatic hydrocarbons, and producing interesting, biologically active secondary metabolites including quinolones, rhamnolipids, lectins, hydrogen cyanide, and phenazines. Production of these products is likely controled by complex regulatory networks making Pseudomonas aeruginosa adaptable both to free-living and pathogenic lifestyles. In addition to being able to colonize a wide variety of environments, Pesudomonas aeruginosa is also a pathogen with a wide host range. PA14, a clinical isolate from a human burn patient, has been demonstrated to cause pathogenesis in such diverse hosts as humans, mice, Caenorhabditis elegans, Drosophila melanogaster, and Arabidopsis thaliana. PA14 is also an excellent model for the study of pathogenesis and biofilm formation. Comparison of PA14 with a less pathogenic previously sequenced P.aeruginosa strain (PAO1; PSEAE) showed that genes that are present in PA14 but absent in PAO1 do not correlate with the virulence of these strains. The authors suggest that virulence in P.aeruginoas is the result of the combination of pathogenicity-related genes that interact in different fashions depending on the genetic background (adapted from http://ausubellab.mgh.harvard.edu/cgi-bin/pa14/annotation/start.cgi).
Properties: Presence of flagella: Yes
Interaction: Animal pathogen in Mammalia; Animal pathogen in Insecta; Plant pathogen
Number of membranes: 2
Number of inteins:0
Statistics: Number of PSEAB entries in the UniProt Knowledgebase: 5886 (557 in UniProtKB/Swiss-Prot + 5329 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    UCBPP-PA14
Genome structure:
Chromosome EMBL accession number CP000438 (circular; 6,537,648 bp) (download entry) (download Genome Reviews).
Reference(s):
[1] PubMed=17038190; [ NCBI , EBI , Israel , Japan ]
Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S., Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M. ;
"Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial.";
Genome Biol. 7:R90.1-R90.14(2006).
Web links:
Official genome site(s):
http://ausubellab.mgh.harvard.edu/cgi-bin/pa14/annotation/start.cgi
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid208963%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Paer_UCBPPPA14
PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p386_Pse_aerug
 EBI Proteome Analysis page



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