Species code:	BRUA2
Taxonomy:	Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella (TaxID: 359391) [NEWT/ NCBI]
Description:	Brucellosis is a major infectious disease for both human and animals. Several Brucella species (B.abortus, B.melitensis and B.suis) have been isolated from many different animals. All three Brucella species cause a severe human disease characterized in its acute phase by undulant fever and in its chronic phase by damage of different organs. Brucellosis is a major problem in the Mediterranean region and parts of Asia, Africa and Latin America. When the infection is localized to the brain or the heart, it can result in a fatal meningitidis or fatal endocarditis, respectively. Brucella abortus (strain 2308) is virulent for humans, cattle and certain other domestic animals. Its genome consists of 2 chromosomes. Despite the high conservation of the genomic backbone shared by the three Brucella species, several important species-specific differences exist. A total of 207 pseudogenes were identified in B.abortus (strain 2308). Sixteen pseudogenes are common to the three species, among which 9 were generated by the same event. Although Brucellae contain a large set of flagellar genes, they display a species-specific gene inactivation and consequently are nonmotile. The inactive genes contain either single point mutations or small deletions and are essential for the activity or the assembly of the flagellum or are key structural proteins of this organelle. The three Brucella species harbor a complete and functional type IV secretion system.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of BRUA2 entries in the UniProt Knowledgebase: 3022 (430 in UniProtKB/Swiss-Prot + 2592 in UniProtKB/TrEMBL)

Genome structure	• Chromosome I, strain 2308 EMBL accession number AM040264 (circular; 2,121,359 bp) (download entry) (download Genome Reviews). • Chromosome II, strain 2308 EMBL accession number AM040265 (circular; 1,156,948 bp) (download entry) (download Genome Reviews).
References	[1] PubMed=16299333; [ NCBI , EBI , Israel , Japan ] Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. ; "Whole-genome analyses of speciation events in pathogenic Brucellae."; Infect. Immun. 73:8353-8361(2005).
Web links	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid359391%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Bmel_ABORTUS2308 PATRIC: http://patric.vbi.vt.edu/genome/overview.php?genomeId=25 PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p16203_Bru_melit RhizoDB: http://xbase.bham.ac.uk/rhizodb/genome.pl?id=968  EBI Proteome Analysis page

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