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NiceZyme View of ENZYME: EC 1.5.99.12

Official Name
Cytokinin dehydrogenase.
Alternative Name(s)
Cytokinin oxidase.
Reaction catalysed
N(6)-dimethylallyladenine + acceptor + H(2)O <=> adenine + 3-methylbut-2-enal + reduced acceptor
Cofactor(s)
FAD.
Comment(s)
  • Converts zeatin and related cytokinins.
  • Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is a dimethylallyl or other prenyl group.
  • Although this activity was previously thought to be catalyzed by a hydrogen-peroxide-forming oxidase, this enzyme does not require oxygen for activity and does not form hydrogen peroxide.
  • 2,6-dichloroindophenol, methylene blue, nitroblue tetrazolium, phenazine methosulfate and Cu(2+) in the presence of imidazole can act as acceptors.
Cross-references
BRENDA1.5.99.12
PUMA21.5.99.12
PRIAM enzyme-specific profiles1.5.99.12
KEGG Ligand Database for Enzyme Nomenclature1.5.99.12
IUBMB Enzyme Nomenclature1.5.99.12
IntEnz1.5.99.12
MEDLINEFind literature relating to 1.5.99.12
MetaCyc1.5.99.12
UniProtKB/Swiss-Prot
O22213, CKX1_ARATH;  Q9T0N8, CKX1_MAIZE;  Q9FUJ3, CKX2_ARATH;  
Q9LTS3, CKX3_ARATH;  Q9FUJ2, CKX4_ARATH;  Q67YU0, CKX5_ARATH;  
Q9LY71, CKX6_ARATH;  Q9FUJ1, CKX7_ARATH;  P58763, CKX_WHEAT;  

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