| Official Name |
|---|
| Sterol 14-demethylase.
|
| Alternative Name(s) |
|---|
| Cytochrome P450 51. |
| Lanosterol 14-alpha-demethylase. |
| Lanosterol 14-demethylase. |
| Obtusufoliol 14-demethylase. |
| Sterol 14-alpha-demethylase. |
| Reaction catalysed |
|---|
| Obtusifoliol + 3 O(2) + 3 NADPH <=> 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- The enzyme (P450) catalyzes successive hydroxylations of the
14-alpha-methyl group and C-15, followed by elimination as formate
leaving the 14(15) double bond.
- This enzyme acts on a range of steroids with a 14-alpha-methyl group.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.13.70 |
| PUMA2 | 1.14.13.70 |
| PRIAM enzyme-specific profiles | 1.14.13.70 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.70 |
| IUBMB Enzyme Nomenclature | 1.14.13.70 |
| IntEnz | 1.14.13.70 |
| MEDLINE | Find literature relating to 1.14.13.70 |
| MetaCyc | 1.14.13.70 |
| UniProtKB/Swiss-Prot |
| Q4PJW3, CP51A_BOVIN; | Q16850, CP51A_HUMAN; | O46420, CP51A_PIG; |
| Q5RE72, CP51A_PONAB; | Q64654, CP51A_RAT; | Q759W0, CP51_ASHGO; |
| P10613, CP51_CANAL; | P50859, CP51_CANGA; | P14263, CP51_CANTR; |
| Q9UVC3, CP51_CUNEL; | Q1ZXH9, CP51_DICDI; | Q02315, CP51_ISSOR; |
| Q5UQI3, CP51_MIMIV; | P0A513, CP51_MYCBO; | P0A512, CP51_MYCTU; |
| Q5IZM4, CP51_MYCVP; | Q12664, CP51_PENIT; | Q09736, CP51_SCHPO; |
| P93846, CP51_SORBI; | O14442, CP51_UNCNE; | P49602, CP51_USTMA; |
| P93596, CP51_WHEAT; | P10614, CP51_YEAST; |
|
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